Endocrine Abstracts

Objective: Treatment with glucocorticoids and mineralocorticoids has changed congenital adrenal hyperplasia (CAH) from a fatal to a chronic lifelong disease. As a result of long-term treatment, including chronic (over-)treatment with glucocorticoids, patients with CAH may develop an adverse cardiovascular risk profile. The objective of this study was to evaluate the cardiovascular risk profile of adult CAH patients.Patients and measurements: In this case...

Infertility is a serious problem in female as well in male CAH patients. The most important cause of male infertility in CAH patients is the presence of testicular adrenal rest tumors (TART). The reported prevalence in adult CAH patients is up to 96%. TART have no malignant features but because of their typical localization near the mediastinum testis, longstanding compression of the seminiferous tubules may lead to obstructive azoospermia and irreversible damage of testicular...

Background: Recently, GATA transcription factors have been linked to the development of Testicular Adrenal Rest Tumours (TART), benign adrenal-like testicular tumours that frequently occur in male patients with congenital adrenal hyperplasia (CAH). The objective of this study is to determine GATA expression in TART and other steroidogenic tissues, examining their discriminative potential and their possible role in the aetiology of TART.Methods: GATA1-6 e...

Context: More reliable parameters than cortisol are needed for assessing correct catheter positioning during adrenal vein sampling (AVS). Plasma metanephrine represents one such alternative.Objective: To determine the utility of adrenal venous (AV) plasma concentrations of metanephrine to establish correct catheter positioning during AVS.Design and methods: We included 86 AVS procedures: 52 ACTH-stimulated and 34 non-stimulated seq...

Background: Testicular Adrenal Rest Tumors (TART) in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD) or 11-hydroxylase deficiency (11OHD) are benign lesions causing testicular damage and infertility. We hypothesize that high ACTH exposure due to poor hormonal control during early life is promoting development of TART later in life.Objective: This study aims to examine the relation between early CAH diagnosis and cons...